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KMID : 0363320100310030620
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 3 p.620 ~ p.630
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Nephroprotective Effects of Manjeonmoktong-san on Cisplatin-induced Rat Acute Renal Failure
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Kim Do-Nyoen
Yoon Keong-Min
Shin Hyeon-Cheol
Kang Suk-Bong
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Abstract
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Purpose:The object of this study was to observe the nephroprotective effects of Manjeonmoktong-san(MJMTS), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure.
Methods:At first, three different dosages of MJMTS extract were orally administered once a day for 28 days. On the 23rd day after MJMTS extract treatment, cisplatin was treated. Then, 5 days after cisplatin treatment, all the rats (6 groups of 8 rats each) were checked in the present study. The changes to the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed.
Results:It showed dramatical decrease on the body weight, increase of serum BUN and creatinine levels were detected in cisplatin control as compared with intact control. In addition marked increase of kidney MDA contests and decrease of kidney GSH contents were also detected in cisplatin control as compared with intact control. it means that cisplatin induced ARF are induced by oxiidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of MJMTS extracts.
Conclusion:This study suggests that MJMTS extracts have favorable effects on the cisplatin-induced rat ARF.
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KEYWORD
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Manjeonmoktong-san(wanquanmutong-san), ARF, Cisplatin, Antioxidant effect
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